Medical researchers at Northwestern University have developed a new blood test that can determine the precise time of your body’s internal clock. Circadian clocks play a key role in regulating a vast array of biological processes, with significant implications for human health. Accurate assessment of physiological time using transcriptional biomarkers found in human blood can significantly improve the diagnosis of circadian disorders and optimize the delivery time of therapeutic treatments.
The new blood test will help doctors and hospital workers make sure that medications are delivered according to your body’s schedule, not the clock on the wall. Details on the patent-pending medical technology are described in the Sept. 10 issue of the journal PNAS
Determining the state of an individual’s internal physiological clock has important implications for precision medicine, from diagnosing neurological disorders to optimizing drug delivery. To be useful, such a test must be accurate, minimally burdensome to the patient, and robust to differences in patient protocols, sample collection, and assay technologies. TimeSignature is a machine-learning approach to predict physiological time based on gene expression in human blood. A powerful feature is TimeSignature’s generalizability, enabling it to be applied to samples from disparate studies and yield highly accurate results despite systematic differences between the studies. This quality is unique among expression-based predictors and addresses a major challenge in the development of reliable and clinically useful biomarker tests.
The software and algorithm will be made available to other researchers for further development, and will also enable them to easily examine the impact of misaligned circadian clocks in a range of maladies, including diabetes and Alzheimer’s disease.
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